A clinical data validated mathematical model of prostate cancer growth under intermittent androgen suppression therapy
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چکیده
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منابع مشابه
A Mathematical Model of Intermittent Androgen Suppression Remedy for Prostate Cancer
Androgen suppression has been the principal modality for treatment of advanced prostate cancer for several decades. Although the tumor response rate to androgen deprivation is initially high, almost all patients relapse within several years due to proliferation of androgenindependent tumor cells. Since Bruchovsky et al. suggested in animal models that intermittent androgen suppression can prolo...
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Prostate cancer progression depends in part on the complex interactions between testosterone, its active metabolite DHT, and androgen receptors. In a metastatic setting, the first line of treatment is the elimination of testosterone. However, such interventions are not curative because cancer cells evolve via multiple mechanisms to a castrate-resistant state, allowing progression to a lethal ou...
متن کاملMathematical modelling of prostate cancer growth and its application to hormone therapy.
Hormone therapy in the form of androgen deprivation is a major treatment for advanced prostate cancer. However, if such therapy is overly prolonged, tumour cells may become resistant to this treatment and result in recurrent fatal disease. Long-term hormone deprivation also is associated with side effects poorly tolerated by patients. In contrast, intermittent hormone therapy with alternating o...
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